Articles, Journals and Studies

 

A Genetic Mutation That Can Affect Mental & Physical Health MTHFR mutations are linked to depression, ADHD, migraines, miscarriage & more

Traci Stein Ph.D., MPH Traci Stein Ph.D., MPH

You many not have heard of MTHFR yet, but it is the acronym for a gene (methylenetetrahydrofolate reductase) that produces an essential enzyme. The acronym for the enzyme is also MTHFR. It’s worth knowing about this gene because it plays a key role with regard to many aspects of emotional and physical health.

https://www.psychologytoday.com/blog/the-integrationist/201409/genetic-mutation-can-affect-mental-physical-health

 

Human Genome Epidemiology (HuGE) Review

“The authors performed a meta-analysis of studies examining the association between polymorphisms in the 5,10- methylenetetrahydrofolate reductase (MTHFR) gene, including MTHFR C677T and A1298C, and common psychiatric disorders, including unipolar depression, anxiety disorders, bipolar disorder, and schizophrenia.”

http://www.biobalance.org.au/_downloads/mthfr-genetic-polymorphisms-and-pscy-disordersa-huge-review-am-j-epidemiol2007.pdf

 

A potential interaction between COMT and MTHFR genetic variants in Han Chinese patients with bipolar II disorder – Received 23 July 2014 Accepted 23 December 2014 Published 6 March 2015

“Bipolar disorder (BPD), also known as manic-depressive illness, is characterised by periods of elevated mood and periods of depression. The two most commonly known clinical subtypes are bipolar-I disorder (BP-I) and bipolar-II disorder (BP-II). BP-II, characterized by recurrent depressive and hypomanic episodes, is frequently regarded as a ‘‘milder form of BP-I’’1 . It is believed that BP-II is greatly under-diagnosed and frequently misdiagnosed in clinical settings2,3, because patients usually seek treatment during depressive episodes but perceive hypomanic episodes as positive experiences1,4. I”

http://www.biobalance.org.au/_downloads/a-potential-interaction-between-comt-and-mthfr-genetic-variants-in-han-chinese-patients-with-bipolar-ii-disorderscireport201531315.pdf

 

Pyroluria- Kryptopyroluria – Integrative Psychiatry 

“Pyroluria is a genetically acquired chemical imbalance in which the body produces an abnormally large number of pyrroles. A pyrolle is a chemical consisting of a 5 membered aromatic ring. These chemicals are the byproduct of hemoglobin synthesis and have no known function in the body; they are normally excreted in the urine. Most people have very few pyrroles in their system at any given time; certain individuals, however, have an unusually high number of pyrroles in their bodies, resulting in a condition known as pyroluria.”

https://www.integrativepsychiatry.net/pyroluria.html

 

10% have this illness but most don’t know it (Pyrrole Disorder) – Article from Body & Soul

“Common symptoms include inability to cope with stress, emotional mood swings and sensitivity to light and sound. It also causes learning difficulties and auditory processing disorder, which means that in a noisy environment, it’s hard to single out the sound you should be listening to. In a classroom environment, that would mean that if other kids were talking, Sophie would struggle to hear the teacher.”

http://www.biobalance.org.au/articles/100

 

 

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