The role of mTOR in depression and antidepressant responses – Life Sci. 2014 Apr 17;101(1-2):10-4. doi: 10.1016/j.lfs.2014.02.014. Epub 2014 Feb 25.
“The aim of this study was to characterize the mTOR signaling cascade in depression and the actions that antidepressant drugs have on this pathway. Herein, a literature review was performed by verification and comparison of textbooks and journal articles that describe the characterization of the mTOR signaling cascade and its relationship to depression and antidepressant drugs, especially ketamine. Postmortem studies have shown robust deficits in the mammalian target of rapamycin (mTOR) signaling in the prefrontal cortex of subjects diagnosed with major depressive disorder. However, besides the mTOR signaling pathway having an antidepressant response to various drugs, this seems to be more associated with antidepressant N-methyl-d-aspartate (NMDA) receptor antagonists, such as ketamine. The characterization of the mTOR signaling pathway in depression and its action in response to antidepressants show great potential for the identification of new therapeutic targets for the development of antidepressant drugs.”
Copyright © 2014 Elsevier Inc. All rights reserved.
Pro-inflammatory versus anti-inflammatory effects of mTOR
Monika Linke Nature Reviews Immunology 15, 599–614 doi:10.1038/nri3901
“There are seemingly contrasting roles of mammalian target of rapamycin (mTOR) in individual cells or models, which mirror contradictory data from the phosphatidylinositol 3-kinase (PI3K) pathway160. These observations might be a consequence of different experimental conditions, such as the analysis of primary versus in vitro-generated cells or cell lines. Alternatively, species-specific differences between mice and humans in the importance of the arginine and nitric oxide system, which is regulated by PI3K–mTOR, might explain these results.”
Regulation of innate immune cell function by mTOR – Thomas Weichhart, Markus Hengstschläger & Monika Linke
Nature Reviews Immunology 15, 599–614 (2015) doi:10.1038/nri3901 Published online 25 September 2015
“The innate immune system is central for the maintenance of tissue homeostasis and quickly responds to local or systemic perturbations by pathogenic or sterile insults. This rapid response must be metabolically supported to allow cell migration and proliferation and to enable efficient production of cytokines and lipid mediators.”
mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists
“The rapid antidepressant response after ketamine administration in treatment resistant depressed patients suggests a possible new approach for treating mood disorders compared to the weeks or months required for standard medications.”
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